What is CBD Isolate? - Overview

CBD is everywhere, and people are adding it to everything from their morning coffee to their hand cream.

As CBD continues to rise in popularity, there’s a dizzying number of ways to take it. Terms like full-spectrum and isolate are thrown around with little explanation. And then, there’s the question about the best way to take CBD. Should you eat it, vape it, swallow it in a pill, or put it on your skin?

This guide will define what CBD isolate is and answer all your burning questions, including whether it will show up on a drug test.

What is CBD Isolate?

The revelation that CBD can be used for a variety of therapeutic and medicinal purposes is a relatively new discovery. It wasn’t until 1963 that Dr. Raphael Mechoulam found out that individual cannabinoids had different effects on the body. In the recent decades, scientists learned that of all the cannabinoids, CBD (short for cannabidiol) and THC had the most potential health benefits.

Therefore, some manufacturers elected to isolate the CBD molecule and offer it by itself in a pure form. A pure CBD isolate won’t have any other cannabinoids like CBG, CBN, THC, THCA, etc.

When you buy CBD, you’ll see two types of CBD products: full-spectrum CBD oil and CBD isolate (aka THC-free).

CBD Isolate

When you hear the term CBD isolate, you can be confident that all the other compounds have been stripped out, and you’re getting virtually pure CBD.

CBD isolate comes in either a fine, white crystalline powder or a slab that can be broken down. In the production process, the cannabidiol molecule is separated from the rest of the molecules in the hemp extract.

  • CBD99%
  • THC0%
  • CBG0%
  • CBN0%
  • Others0%

Full-spectrum CBD

Full-spectrum CBD is also referred to as full-spectrum CBD extract, whole plant CBD extract, or full spectrum hemp extract.

Full-spectrum includes all of the cannabinoids that are present in the hemp plant plus all of the waxes, terpenes, fatty acids, chlorophyll, and more.

  • CBD90%
  • THC1%
  • CBG2%
  • CBN2%
  • Others5%

One of the key reasons people prefer CBD isolate is that it is guaranteed to contain no THC. This is important for people who want to ensure that their CBD is 100% free of THC, the psychoactive cannabinoid that results in “getting high”. It’s also vital for people who are tested regularly for drugs, whether it’s for a job application, their current career, or they need to be THC free for another reason.

Even though full-spectrum CBD can be marketed without THC, the truth is that it can still have up to 0.3% THC. This is enough to show up on a drug test.

Benefits of CBD Isolate

What Plant Does CBD Come From?

CBD, short for Cannabidiol, comes from the flowering portion of the cannabis plant. This miracle plant is part of the Cannabaceae family, which includes the following plant species:

Because there are different types of cannabis, some with psychoactive THC, and others without, there has been confusion between the various terms, and they’re often mistakenly used.

For example, hemp and marijuana are sometimes used interchangeably, even though they are different. Hemp is not marijuana. Instead, hemp is a variety of cannabis that contains little to no THC (less than 0.3%), while marijuana is a type of cannabis plant that contains high amounts of THC (Tetrahydrocannabinol). Both hemp and marijuana plants can both produce CBD. The primary difference is in the THC content.

Hemp has been cultivated for over 9,000 years for a variety of industrial purposes. In fact, the first draft of the Declaration of Independence was written on paper made of hemp. During World War II, hemp production became more widespread, but it became illegal due to misinformation and confusion that it was the same thing as marijuana. Propaganda films like Reefer Madness portrayed marijuana as a dangerous drug, and it led to the criminalization of all types of cannabis, including hemp.

CBD can be extracted from both hemp and marijuana plants. However, while hemp-derived CBD is currently legal in all 50 states, marijuana-derived CBD is only permitted in states that have legalized marijuana.

How is CBD Isolate Extracted?

The first steps in making CBD isolate are the same as extracting full-spectrum CBD. After the initial extraction, there are variations in how the CBD is isolated and removed, and the process will differ based on the manufacturer.

Here is the most common step-by-step process:


Step 4

The crude extract is refined to eliminate unwanted compounds. The process usually involves dissolving the extract in an organic solvent and then freezing the solution to cryo teperatures which causes the fats and waxes to separate from the cannabinoids.

Step 5

Once the cannabinoids separate from the wax, the solvent is evaporated from the solution resulting in a purified crude extract.


Step 6

The resulting crude extract is then dissolved into a non-polar solvent like hexane or pentane which causes the CBD molecule to become “isolated” from the rest of the molecules in the the solution. The solution is chilled and larger crystals of CBD begin to form.

Step 7

Step 7: The large crystals are then melted down and the hexane or pentane is removed through vacuum and heat.

Alternative Extraction Processes

Flash chromatography is another type of chemical extraction process where the THC is washed away leaving a broad spectrum CBD Oil. This process creates a beautiful CBD extract, but it still needs further refinement to isolate the CBD.

From here, the extract is mixed with solvents, such as hexane and ethyl acetate. The solution evaporates, leading to crystallization of the CBD. To ensure the crystals are safe for consumption, they undergo a chemical washing process and additional filtration.

Types of CBD

CBD Isolate Powder

In powder form, CBD isolate looks like a white powder. It tends to resemble powdered sugar, though it can also come in a larger crystallized form. It is incredibly versatile, and it contains no taste or odor (assuming it’s been manufactured correctly). There may be a slight residual cherry flavor, but it should be subtle, if detectable at all.

Having CBD isolate in powder form makes it easier to dose as well as mix with food and drinks. Instead of paying for overpriced concoctions, you can buy CBD isolate powder by itself and create topicals, edibles, and beverages.

CBD Isolate Slab

Slabs are ideal for people who want to vape or dab their CBD. These consumption methods allow users to inhale pure CBD vapor without any other chemicals or contaminants. Another advantage of using CBD isolate slab for vaping is that it can enter the bloodstream more quickly. Instead of digesting or applying CBD to the skin, the CBD goes directly to your circulatory system, allowing you to feel the effects and experience the benefits sooner. CBD isolate slabs can also be used for cooking and edibles, and they can be combined and smoked with herbs if desired.

Other Types of CBD Isolate

Though CBD isolate’s most common forms are power and slabs, there are other CBD isolate options as well:

With Terpenes

Terpenes are volatile molecules found in plants, fruits and vegetables and are responsible for smell and taste. They’re considered adaptive in nature. For example, the terpenes that the plants produce protect them from predators. In addition to providing scents, terpenes also have therapeutic benefits, similar to cannabinoids. For example, limonene is a terpene found in cannabis, fruit rinds, grapefruit, and rosemary. It has a citrus smell and is associated with stress relief and improved mood. It also has anti-inflammatory and anti-fungal properties.

Types of Terpenes

  • Synthesized – Synthetic terpenes are made in a lab, not found naturally in the plant. You can think of synthesized terpenes as adding strawberry flavoring to a piece of candy instead of eating a real strawberry.
  • Real plant based – These terpenes are botanically derived from plants other than the cannabis plant. Examples include linalool from lavender, myrcene from cloves, and alpha-pinene from pine needles.
  • Real cannabis-based – Of the 20,000 terpenes in existence, there are 100 that are found in cannabis. There’s also overlap, and some of the terpenes in cannabis are found in other plants as well. Myrcene, mentioned above, is one of the primary terpenes in cannabis.

CBD + Terpenes

Terpenes give plants their distinct smell and taste. By combining these natural compounds with CBD, producers have been able to recreate an effect associated with cannabinoids while creating new flavor profiles. Some of the more creative of these terpene profiles include:

Maui Wowie

Visit Hawaii without the expensive airfare. This fragrant terpene profile recreates the legendary strain with a distinct pineapple aroma.

Lemon Haze

It’s hard not to feel happy when you smell a lemon. Bring back that citrus nostalgia with a concentration of terpinolene, which has a distinct woody aroma with plenty of citrus tones.

Blueberry Kush

This terpene profile combines sweet berry notes with a hint of earth. Typically, Blueberry Kush is associated with high THC-content, but you’ll be able to avoid THC completely by opting for the CBD isolate version.

Girl Scout Cookies

If you’re craving a sweet snack that won’t sabotage your diet, opt for the Girl Scout Cookies CBD isolate. The terpenes added include linalool, myrcene, pinene, limonene, and caryophyllene. Its combination of sweet and earthy with a hint of pungency can satisfy any craving.

Blue Dream

This terpene profile is nearly identical to Girl Scout Cookies, though it tends to receive higher reviews than GSC

Other Forms of CBD

Depending on how CBD is processed and how many steps have been taken in its refinement, there can be various forms of cannabidiol. Here are the most common you’ll see as you search for CBD to buy:


Crude CBD is minimally processed and often bought in bulk at wholesale prices.


CBD distillate is less refined than CBD isolate. It’s basically what CBD isolate is before it’s gone through its final purification steps. Therefore, CBD distillate can contain other cannabinoids like terpenes and various plant materials.


CBD crystals are considered the purest form of CBD available. You’ll often see a purity rating ranging from 90% to 99%, and this indicates the concentration of pure cannabidiol. This number indicates the presence of other contaminants like terpenes. The higher the number, the purer the CBD is.


Winterized CBD has gone through an alcohol wash, which is a step in the extraction process that further purifies CBD. In this step, potentially harmful compounds are removed, such as waxes. The term winterization comes from the fact that the CBD oil is frozen for 24 hours, which allows for the separation of the contaminants.

How Do You Use CBD Isolate?

There are a variety of “delivery methods” that allow you to get the full benefits of CBD. Whether you want to inhale them, put them on your skin, or ingest them, you have countless options.


When you cook with CBD, your body can easily absorb and digest the compounds. This form of consumption is best if you’re not suffering from an acute condition where you need immediate relief. You won’t taste anything (unless you’ve mixed your CBD with a carrier oil or spice).

Because CBD can enhance feelings of well-being, you may end up enjoying the food (and company) more than usual!


Consuming CBD sublingually means putting the powder directly underneath your tongue. To experience the full effects, you should hold the powder in place for about one minute. By placing it under your tongue, your mucous membranes will absorb the powder and deliver it directly to your bloodstream. This method bypasses the digestion process, which can delay and dilute the effects.


You can also apply CBD directly to your skin. There are a variety of DIY methods that allow you to use CBD isolate to create your own topical products, such as lotions, balms, salves, creams, and moisturizers. The advantage of a topical is that you can spot treat an area of localized pain relief. Topicals can also help treat inflammation, dryness, irritation, or blemishes.

In addition to applying topicals directly to the skin for absorption, you can also use CBD isolate to make soaps, bath bombs, and other bath products.


For maximum convenience and dosage control, put your CBD isolate in a capsule and swallow it. No cooking or DIY experience required!

Does CBD Isolate Show up on a Drug Test?

In general, CBD shouldn’t show up on a drug test because it’s not supposed to contain THC. However, full-spectrum CBD products can contain trace amounts of THC. Further, non-isolated products tend to contain other plant compounds that may not be tested. As a result, you could be unknowingly consuming THC, which would yield a positive drug test result.

One of the most significant advantages of CBD isolate is that it is pure CBD. This means that it should contain absolutely zero THC.

To sum up, no, CBD isolate should not show up on a drug test.

Cannabinoids Present in Cannabis

Though CBD is currently getting the most media attention, there are over 100 known cannabinoids found in cannabis. Further, new research has found that cannabinoids aren’t unique to the cannabis plant. They’re also found in a variety of other plant species, including echinacea, the electric daisy, Japanese Liverwort, Helichrysum, and cacao.

As a side note, the “good feeling” that comes from eating chocolate is due to a cannabinoid present in cacao that’s similar to THC.

Some of the most common cannabinoids used for medicinal and recreational purposes include:

  • Cannabidiol (CBD) – This cannabinoid is the most abundant, contributing up to 40% of cannabis resin. It’s also been found that it can balance out the effects of THC. What this means is that a plant with high levels of both THC and CBD may be consumed, and the THC effects will be less than if someone consumed the same amount of THC without any CBD.
  • Cannabigerol (CBG) – Like CBD, this cannabinoid is also non-psychoactive. Early research suggests that CBG obstructs GABA uptake in the brain, which can potentially help with anxiety, mood, and sleep disorders. It was also studied in the 1990s as a glaucoma treatment because it’s been shown to reduce intraocular pressure.
  • Cannabinol (CBN) – Because of its sedative properties, CBN is considered to be “mildly psychoactive.” It was the first cannabinoid to be isolated and was thought to be the main reason for the psychoactive effects of marijuana before they discovered THC.
  • Cannabicyclol (CBL) – So far, CBL is one of the least studied cannabinoids, so not much is known about it yet. Scientists have learned that it has no psychoactive properties and have yet to determine its exact benefit. For now, they’re saying that it’s part of the “entourage effect,” which maintains that taking full-spectrum cannabis can yield superior results due to the synergies of taking all of the cannabinoids present in the plant.
  • Tetrahydrocannabinolic Acid (THCA) – Found in raw cannabis, THCA does not produce the intoxicating effects of THC. However, when the cannabis plant dries, THCA converts to THC. The process is expedited when the plant is exposed to heat. Therefore, people can obtain the same effects of THC by smoking or vaporizing THCA.
  • Cannabidiolic Acid (CBDA) – CBDA is similar to THCA. It’s been shown to contribute to the anti-inflammatory effects of consuming cannabis products.
  • Cannabichromene (CBC) – You’ll often find CBC in topical cannabis products. Not only does it have the potential to relieve pain and reduce inflammation, but it can also promote bone growth while inhibiting tumor and cancer cell growth.
  • Tetrahydrocannabinol (THC) – Also known as delta-9-tetrahydrocannabinol, THC creates the “euphoric high” that marijuana is known for. It affects mood, motor function, emotion, perception, and cognition.

Ailments that CBD Is Reported to Help With

Studies have revealed a wide array of benefits associated with CBD use. However, manufacturers are not allowed by the FDA to make any claims that their products are meant to cure or treat any diseases. Currently, the only FDA-approved CBD product on the market for medical use is a prescription drug to treat epilepsy.

Still, there are some studies and countless anecdotes about CBD helping with the following:

Pain Relief

The use of marijuana for pain relief dates back nearly 5,000 years. Now that CBD has been identified as the cannabinoid responsible for some of the effects, companies are coming out of the woodwork to fulfill market demand.

Reduce Anxiety and Depression

These conditions are widespread and becoming increasingly common in children. Taking prescription drugs can lead to a whole new crop of problems. However, evidence shows that CBD can help regulate serotonin in the body while also aiding in sleep.

Reduce Cancer-related Symptoms

Patients undergoing chemotherapy and radiation treatment report feeling nauseous and having zero appetite. CBD-administered products can help increase appetite and aid in digestion. There’s also promising research showing that CBD can reduce cancer symptoms and even potentially fight cancer.

Improve Skin

Because CBD can help with inflammation and acne is an inflammatory process, it makes sense that both topical and ingested CBD can improve skin conditions.

Improve Neurological Conditions

CBD is currently being researched to help with conditions like multiple sclerosis, epilepsy and Parkinson’s disease, and Alzheimer’s. Preliminary studies suggest improved quality of life and a stabilization in the conditions’ decline.

Improved Cardiovascular Health

Because stress and anxiety are associated with high blood pressure, some people taking CBD have experienced lowered blood pressure and therefore better cardiovascular health. There could also be antioxidants present in CBD that bolster the health and longevity of cells in this region of the body.

The reason CBD has been identified to help with so many ailments and why consumers are so optimistic has to do with how CBD (and other cannabinoids) interacts with the body’s endocannabinoid system (ECS). It’s believed that cannabinoids return various systems in the body to homeostasis, meaning that cannabis products can identify where the body is struggling and help target those areas.

Any Side-effects Associated With CBD Isolate?

CBD is generally well-tolerated, but there are some things that can go wrong if you’re not careful. Potential side effects include:

  • Dry mouth
  • Diarrhea
  • Drowsiness and fatigue
  • Reduced appetite

If you’re taking any prescription medications, check with your doctor for any potential drug interactions.

Another thing to watch out for is the presence of waxes in CBD if you plan on vaping or smoking. It’s believed that the waxes can build up in the lungs over time and lead to complications. By purchasing 99% or greater CBD isolate, you can be reasonably certain that those waxes have been removed.

How to Determine CBD Dosage

Because this product category is so new, no standard dosages have been established yet by the FDA or any other regulatory bodies.

The good news is that with CBD isolate, you have total control over your dosing. When you’re new to CBD, it’s smart to start with an average does and then go up or down from there. Alternatively, you could start with a very small dose and increase it when you feel comfortable.

Typically, experts recommend starting at a dose of 5 to 10 mgs up to twice per day. This is a typically standard dose. In some products, especially tinctures, you can get doses as small as 1 to 3 mg. You can start with a few drops each day and continue adding if you have no ill effects or fail to experience anything positive.

But again, there is no “perfect” dose that’s been established. CBD intake is a highly individualized process.

What to Watch out for When Buying CBD

The booming CBD market has been referred to as the “green rush,” and there are plenty of unscrupulous businesses eager to take your money.

It’s important to find a reputable company that can produce third-party lab test results. By having these results, you’ll know exactly what you’re consuming and what to expect. Check labels very carefully and look for the following:

  • The concentration of CBD in each serving or package.
  • Third-party lab testing (and viewable results) to ensure that what’s on the label is accurate.
  • The country or region where the hemp was grown and processed. The company’s website should mention that all products were manufactured to a high standard and with responsible practices.

Where To Buy CBD Isolate

CBD Isolate for Sale

If you’re interested in buying CBD isolate for personal use, the most comprehensive source is Buy CBD Oil Online. In addition to supplying powder, slabs, and terpene-infused crystals, they also have a range of ready-made products from a variety of top-notch brands, including Charlotte’s Web™, Bluebird Botanicals™, and Best Life Hemp™.

If you’re a pet owner, you’ll be pleased to see an array of options, ranging from CBD tinctures to treats and chews.

CBD Isolate Wholesale

If you have a favorite brand and you want to buy in bulk (either for personal use or to resell), then it pays to go direct to the manufacturer. BuyCBDOilOnline for example, can sell you CBD isolate in quantities ranging from 500 to 1,000 grams.


The passage of the 2018 Farm Bill expanded hemps legal status, making it more widely available. As more companies clamor to introduce their products, it can mean even more confusion and misinformation to the general public. By knowing what products like CBD isolate are and what to look for when you buy them, you’ll have the best chance of making an informed decision.